Effect of gestational diabetes on blood sugar, liver and renal function tests.

OBJECTIVE Type 2 diabetes adversely affects the liver and kidney function tests. This study was conducted to determine that either the liver and kidney functions are disturbed in the patients having gestational diabetes mellitus (GDM). METHODS One hundred and three women with GDM, and 97 healthy pregnant women (HPW) in their third trimester were registered in the Obs/Gyn Unit of Khyber Teaching Hospital, Peshawar in the time period Apr-Sep 2012. Blood sugar level, glycosylated haemoglobin status HbAlc, haemoglobin concentration, platelet count, liver function tests including alanine amino transferase (ALT), alkaline phosphatase (ALP) and bilirubin, renal function tests including urea and creatinine were determined. RESULTS Blood glucose level and HbAlc of GDM was significantly higher (p < 0.001) than HPW. Fasting and random blood glucose and HbA1c of GDM and HPW were 110.90 +/- 9.10 vs 84.68 +/- 7.01 mg/dl, 148.53 +/- 7.21 vs 124.42 +/- 9.46 mg/dl and 6.49 +/- 1.20 vs 4.99 +/- 0.55 respectively. Haemoglobin percentage, platelet count, ALT, ALP, serum bilirubin and urea were not significantly different among the two groups. However, mean serum creatinine (0.82 +/- 0.32 mg/dl) in GDM was significantly higher (p < 0.05) than in HPW (0.74 +/- 0.15 mg/dl). CONCLUSION In gestational diabetes the LFTs may not be disturbed, however serum creatinine value is increased.